THOMAS BRIESE, PH.D.

Associate Director, Center for Infection and Immunity
Associate Professor of Clinical Epidemiology 

Mailman School of Public Health, Columbia University

Phone: 212.342.9035
Fax: 212.342.9044
Email: tb2047@columbia.edu

EDUCATION & TRAINING

  • Freie Universität, Berlin, Germany, MS, 1983
  • Freie Universität, Berlin, Germany, Ph.D., Biology, 1987
  • Max-Planck-Institut für molekulare Genetik, Berlin, Germany, Postdoctoral Fellow, 1987-88
  • Institute of Virology, Freie Universität Berlin, Germany, Postdoctoral Fellow, 1989-90
  • Institute of Virology, Freie Universität Berlin, Germany, Assistant Researcher, 1991-92
  • University of California, Irvine, CA, Visiting Assistant Researcher, Department of Neurology, 1992-94
  • Freie Universität Berlin, Germany, Assistant Researcher, Institute of Virology, 1994-95
  • Bundesforschungsanstalt f Viruskrankheiten d. Tiere, Researcher, Institute of Microbiology, Tübingen, Germany, 1995-96
  • University of California, Irvine, CA, Assistant Adjunct Professor, Dept. of Neurology, 1997-2002

BIO

Thomas Briese, Ph.D. is Associate Professor of Clinical Epidemiology at the Mailman School of Public Health at Columbia University. He obtained his scientific education at the Freie University in Berlin, the Max Planck Institute for Molecular Genetics, and the University of California at Irvine. He pioneered state-of-the-art methods in molecular biology to study the involvement of infectious agents in chronic and neuropsychiatric diseases, as well as in acute diseases.

SCIENTIFIC INTERESTS

Dr. Briese's research interests include the molecular epidemiology of emerging viral diseases, virus-host cell interactions, and innovative approaches to pathogen diagnosis and discovery. Dr. Briese was responsible for cloning the genome of Borna disease virus, a novel infectious agent potentially linked to some mental disorders. His achievements have been recognized by receipt of an Albertson Young Investigator Award from the National Alliance for Research on Schizophrenia and Depression. Another successful application of these powerful molecular techniques was the identification of the flavivirus responsible for the New York City encephalitis epidemic in 1999. In 2003, Dr. Briese participated in the investigation of the SARS epidemic, during which he visited and collaborated with Beijing research institutions by invitation of the Chinese Ministry of Science and Technology. He also served as an adviser to WHO. Current research efforts include the advancement of molecular detection tools for the rapid identification of potential bio-threat agents. In addition, Dr. Briese is involved in multi-center and birth cohort studies using molecular methods to assess the potential role of infection in disorders such as autism and schizophrenia.

PUBLICATIONS

  • Savji N, Palacios G, Travassos da Rosa A, Hutchison SK, Celone C, Hui J, Briese T, Calisher CH, Tesh RB, Lipkin WI (2011) Genomic and phylogenetic characterization of Leanyer virus, a novel orthobunyavirus isolated in northern Australia.  J Gen Virol.  2011 March 14.  Epub ahead of print.
  • Honkavuori K, Shivaprasad HL, Briese T, Street C, Hirschberg DL, Hutchison SK, Lipkin WI (2011) Novel picornavirus in turkey poults with hepatitis, California, USA.  Emerg Infect Dis.  2011 March;17(3):480-7.
  • Palacios G, Briese T, Lipkin WI (2010) Microbe hunting in laboratory animal research.  ILAR J.  2010;51(3):245-54.
  • Thaitrong N, Liu P, Briese T, Lipkn WI, Chiesl TN, Higa Y, Mathies RA (2010) Integrated capillary electrophoresis microsystem for multiplex analysis of human respiratory viruses. Anal Chem. 2010 Dec 15;82(24):10102-9.  Epub 2010 Nov 29.
  • Keller DL, Honkavuori KS, Briese T, Lipkin WI, Muthuswamy A, Steinberg H, Sladky KK (2010) Proventricular dilatation disease associated with Avian bornavirus in a scarlet macaw (Ara macao). J Vet Diagn Invest.  2010 Nov;22(6):961-5.
  • Quan PL, Firth C, Street C, Henriquez JA, Petrosov A, Tashmukhamedova A, Hutchison SK, Egholm M, Osinubi MO, Niezgoda M, Ogunkoya AB, Briese T, Rupprecht CE, Lipkin WI.  MBio.  2010 Oct 12;1(4).
  • Allison AB, Palacios G, Travassos da Rosa A, Popov VL, Lu L, Xiao SY, DeToy K, Briese T, Lipkin WI, Keel MK, Stallknecht DE, Bishop GR, Tesh RB (2010) Characterization of Durham virus, a novel rhabdovirus that encodes both a C and SH protein. Virus Res.  2011 Jan;155(1):112-22. Epub 2010 Sept 21.
  • Epstein, J. H., P-L Quan., T. Briese, C. Street, O.J. Jabado, S. Conlan, S. Ali Khan, D.M. Verdugo, J. Hossain, S. K. Hutchison, M. Egholm, S. P. Luby, P. Daszak, and W. I. Lipkin (2010) Identification of GBV-D, a Novel GB-like Flavivirus from Old World Frugivorous Bats (Pteropus giganteus) in Bangladesh.  PLoS Pathog. 2010 Jul 1;6:e1000972.
  • Albariño, C. G., G. Palacios, M. L. Khristova, B. R. Erickson, S. A. Carroll, J. A. Comer, J. Hui, T. Briese, K. St. George, T. G. Ksiazek, W. I. Lipkin, and S. T. Nichol (2010) High diversity and ancient common ancestry of lymphocytic choriomeningitis virus.  Emerg. Infect. Dis. 16, 1093-1100.
  • Jabado, O. J., S. Conlan, P.-L. Quan, J. Hui, G. Palacios, M. Hornig, T. Briese, and W. I. Lipkin (2010) Nonparametric methods for the analysis of single-color pathogen microarrays.  BMC Bioinformatics 11, 354; http://www.biomedcentral.com/1471-2105/11/354.
  • Quan, P.-L., T. A. Wagner, T. Briese, T. R. Torgerson, M. Hornig, A. Tashmukhamedova, C. Firth, G. Palacios, A. Baisre-De-Leon, C. D. Paddock, S. K. Hutchison, M. Egholm, S. R. Zaki, J. E. Goldman, H. D. Ochs, and W. I. Lipkin (2010) Astrovirus encephalitis in a boy with X-linked agammaglobulinemia.  Emerg. Infect. Dis. 16, 918-925.
  • Gray, P., S. Hoppes, P. Suchodolski, N. Mirhosseini, S. Payne, I. Villanueva, H. L. Shivaprasad, K. S. Honkavuori, W. I. Lipkin, T. Briese, S. M. Reddy, and I. Tizard (2010) Use of avian bornavirus isolates to induce proventricular dilatation disease in conures.  Emerg. Infect. Dis. 16, 473-479.
  • Palacios, G., N. Savji, J. Hui, A. Travassos da Roas, V. Popov, T. Briese, R. Tesh, and W. I. Lipkin (2010) Genomic and phylogenetic characterization of Merino Walk virus, a novel arenavirus isolated in South Africa.  J. Gen. Virol. 91, 1315-1324.
  • Palacios, G., M. Hornig, D. Cisterna, N. Savji, A. V. Bussetti, V. Kapoor, J. Hui, R. Tokarz, T. Briese, E. Baumeister, and W. I. Lipkin (2009) Streptococcus pneumoniae coinfection is correlated with the severity of H1N1 pandemic influenza. PLoS One 4(12), e8540.
  • Villanueva, I., P. Gray, N. Mirhosseini, S. Payne, S. Hoppes, K. S. Honkavuori, T. Briese, D. Turner, and I. Tizard (2010) The diagnosis of proventricular dilatation disease: Use of a Western blot assay to detect antibodies against avian Borna virus.  Vet. Microbiol. 143, 196-201.
  • Fan, L., T. Briese, and W. I. Lipkin (2009) Z Proteins of New World Arenaviruses Bind RIG-I and Interfere with Type I Interferon Induction.  J. Virol. 84, 1785-1791.
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