Simon Anthony

SIMON ANTHONY, D.PHIL.

Associate Research Scientist

Phone: 212.342.9051
Fax: 212.342.9044
Email: sja2127@columbia.edu

 
EDUCATION & TRAINING
  • University of Wales, Bangor, United Kingdon, B.Sc. Zoology, 2001
  • University of Oxford/Institute for Animal Health, Pirbright, United Kingdom, D.Phil, Molecular Virology, 2007

SCIENTIFIC INTERESTS

My research focuses on infectious and emerging pathogens that threaten the conservation of endangered species in both wild and captive populations.   It focuses on the characterisation of known viral, bacterial and protozoal pathogens, and the discovery of novel agents in wildlife.  My work aims to elucidate mechanisms of pathogen evolution in wildlife reservoirs and understand the processes by which they emerge as disease causing agents in new hosts (including humans). 

Current projects include 1) virus discovery in wildlife from global hotspots of emerging disease, 2) investigating the impact of disease on the decline of the endangered thick-billed parrot in the Sierra Madres of northern Mexico, 3) characterisation of cetacean retroviruses, and IV) disease investigations of marine mammals 

PUBLICATIONS
  • Bogich, T.L; Anthony, S.J; Nichols, J.D.  Surveillance theory applied to virus detection: A case for targeted discovery (Special Report).  Future Virology. (2013) 8(12), 1201–1206.  DOI: 10.2217/FVL.13.105
  • Anthony, S.J; Garner, M.M; Palminteri, L; Navarrete-Macias, I; Sanchez-Leon, M.D; Briese, T; Daszak, P; Lipkin, W.I.  West Nile virus in the British Virgin Islands.  EcoHealth: 11(2) doi:10.1007/s10393-014-0910-6
  • Anthony, S.J; Epstein, J.H; Murray, K.A; Navarrete-Macias, I; Zambrana-Torrelio, C.M; Solovyov, A; Ojeda-Flores, R; Arrigo, N.C; Islam, A; Ali Khan, S; Hosseini, P; Bogich, T.L; Olival, K.J; Sanchez-Leon, M.D; Karesh, W; Goldstein, T; Luby, S.P; Morse, S.S; Mazet, JAK; Daszak, P; Lipkin, W.I.  A strategy to estimate unknown viral diversity mammals.  (2013). mBio 4(5): e00598-13. doi:10.1128/mBio.00598-13
  • Zhu, G; Wang, R; Xuan, F; Daszak, P; Anthony, S.J; Zhang, S; Zhang, L; He, G.  Characterization of recombinant H9N2 influenza viruses isolated from wild ducks in China.  Vet. Microbiol. 2013.
  • Anthony, S.J; St. Leger, J.A; Navarrete-Macias, I; Nilson, E; Sanchez-Leon, M; Liang, E; Seimon, T; Jain, K; Daszak, P; Briese, T; Lipkin, W.I. Polyomavirus in a common dolphin (Delphinus delphis) with tracheobronchitis. (2013).  PloS One.  In Press
  • Goldstein, T; Mena, I; Anthony, S.J; Medina; R; Robinson, P.W; Greig, D.J; Costa, D.P; Lipkin, W.I; Garcia-Sastre, A;Boyce, W .M. Pandemic H1N1 Influenza Isolated from Free-Ranging Northern Elephant Seals in 2010 off the Central California Coast. (2013). PLoS One. 8(5): e62259. doi:10.1371/journal.pone.0062259
  • Quan, PL; Firth, C; Conte, J.M; Williams, S.H; Zambrana-Torrelio, C; Anthony, S.J; Ellison, J.A; Gilbert, A.T; Kuzmin, A.V; Niezgoda, M.N; Osinupi, M.O.V; Recuenco, S; Markotter, W; Breiman, R; Kalemba, L; Malekani, J; Lindblade, K.A; Rostal, M.K; Ojeda-Flores, R; Suzan, G; Davis, L.B; Blau, D.M; Ogunkoya, A.B; Alvarez-Castillo, D.A; Morgan, D; Ngam, S; Akaibe, D; Agwanda, B; Briese, T; Epstein, J.H; Daszak, P; Rupprecht, C.E; Holmes, E.C; Lipkin, W.I.  Bats a major natural reservoir for hepaciviruses and pegiviruses. (2013). doi/10.1073/pnas.1303037110.  PNAS. 110: 8194-8199. 10.1073/pnas.1303037110
  • Anthony, S.J; Ojeda-Flores, R; Rico-Chavez, O; Navarrete-Macias, I; Zambrana-Torrelio, C; Rostal, M.K; Epstein, J.H; Tipps, T; Liang, E; Sanchez-Leon, M.D; Sotomayor-Bonilla, J; Aguirre, A.A; Avila-Flores, R; Medellin, R.A; Goldstein, T; Suzan, G; Daszak, P; Lipkin, W.I.  Coronaviruses in bats from Mexico. (2013). J.Gen Virol.  94: 1028-38. doi: 10.1099/vir.0.049759-0
  • Olival, K.J; Islam, A; Yu, M; Anthony, S.J; Epstein, J.H; Khan, S.A; Khan, S.U; Crameri, G; Wang, LF; Lipkin, W.I; Luby, S.P; Daszak, P.  Filovirus Infection in Fruit Bats (Rousettus leschenaultii), Bangladesh (2013). Emerg. Infec. Dis. DOI: http://dx.doi.org/10.3201/eid1902.120524 
  • Anthony, S.J; St Leger, J.A; Pugliares, K; Ip, H.S; Chan, J.M; Carpenter, Z.W; Navarette-Macias, I; Sanchez-Leon, M; Saliki, J.T; Pedersen, J; Karesh, W; Daszak, P; Rabadan, R; Rowles, T; Lipkin, W.I.  Emergence of fatal influenza in New England Harbor seals.  (2012).mBio 3(4):e00166-12. doi:10.1128/mBio.00166-12
  • Darpel KE, Monaghan P, Simpson J, Anthony SJ, Veronesi E, Brooks HW, Elliott H, Brownlie J, Takamatsu HH, Mellor PS, Mertens PPC (2012) Involvement of the skin during bluetongue virus infection and replication in the ruminant host.Veterinary Research30;43(1):40. doi: 10.1186/1297-9716-43-40. 
  • Smith KM, Anthony SJ, Switzer, WM, Epstein JH, Seimon T, Jia H, Sanchez MD, Huynh TT, Galland GG, Shapiro SE, Sleeman JM, McAloose D, Stuchin M, Amato G, Kolokotronis SO, Lipkin WI, Karesh WB, Daszak P, Marano N (2011) Zoonotic viruses associated with illegally imported wildlife products.  Plos One7(1): e29505. doi:10.1371/journal.pone.0029505
  • Anthony SJ, Darpel KE, Belaganahalli MN, Maan S, Nomikou K, Sutton G, Attoui H, Mertens PPC.  (2011) RNA segment 9 exists as a duplex concatemer in an Australian strain of epizootic haemorrhagic disease virus (EHDV): Genetic analysis and evidence for the presence of concatemers as a normal feature of orbivirus replication. Virology 2011. 420:164-71.
  • Ng TFN, Willner D, Lim YW, Schmieder R, Chau B, Nilsson C, Anthony SJ,  Ruan Y, Rohwer F, Breitbart M (2011) Broad surveys of DNA viral diversity obtained through viral metagenomics of mosquitoes. PloS One, Vol 6 (6): e20579. 
  • Darpel KE, Langner KFA, Nimtz M, Anthony SJ, Brownlie J; Takamatsu HH, Mellor PS, Mertens PPC (2011) Saliva proteins of vector culicoides modify structure and infectivity of Bluetongue virus particles. PLoS One, 6:1-12 (e17545).
  • Maan, N; Maan, S; Nomikou, K; Johnson, DJ; El Harrak, M; Madani, H; Yadin, H; Incoglu, S; Yesilbag, K; Allison, AB; Stallknecht, D; Batten, C; Anthony, SJ; Mertens, PPC (2010) RT-PCR assays for seven serotypes of epizootic haemorrhagic disease virus and their use to type strains from the Mediterranean region and North America.  PLoS One 2010, 5:1-13 (e12782).
  • Anthony, SJ; Darpel, KE; Maan, S; Sutton, G; Attoui, H; Mertens, PPC (2010) The core protein VP6 of epizootic haemorrhagic disease virus (EHDV) exists as two exclusive homologues. Virus Genes 40(1): 67-75. 
  • Veronesi, E; Darpel, KE; Hamblin, C; Carpenter, S; Takamatsu, HH; Anthony, SJ; Elliot, H; Mertens, PPC; Mellor, PS (2009) Viraemia and clinical disease in Dorset Poll sheep following vaccination with live attenuated BTV vaccines serotype 16 and 4. Vaccine 2010 Feb 3;28(5):1397-403. Epub 2009 Nov 4.
  • LaMere, SA; St.Ledger, JA; Schrenzel, MD; Anthony, SJ; Rideout, BA; Salomon, DR (2009) Molecular characterization of a novel gammaretrovirus in killer whales (Orcinus orca).   Journal of Virology 2009 Dec;83(24):12956-67. Epub 2009 Oct 7.
  • Nomikou, K; Dovas, CI; Maan, S; Anthony, SJ; Samuel, A; Papanastassopoulou, M; Koumbati, M; Mangana, O; Mertens, PPC (2009) Evolution and phylogenetic analysis of full-length VP3 genes of Eastern Mediterraneanbluetongue virus isolates. PloS One 2009 Jul 30;4(7):e6437.
  • Anthony, SJ; Maan, N; Maan, S; Sutton, G Attoui, H; Mertens, PPC (2009) Genetic and phylogenetic analysis of the core proteins VP1, VP3, VP4, VP6 and VP7 of epizootic haemorrhagic disease virus (EHDV). Virus Research 2009 Nov;145(2):187-99. Epub 2009 Jul 24.
  • Anthony, SJ; Maan, N; Maan, S; Sutton, G Attoui, H; Mertens, PPC (2009) Genetic and phylogenetic analysis of the core proteins VP1, VP3, VP4, VP6 and VP7 of epizootic haemorrhagic disease virus (EHDV). Virus Research 2009 Nov;145(2):187-99. Epub 2009 Jul 24.
  • Anthony, SJ; Maan, N; Maan, S; Sutton, G Attoui, H; Mertens, PPC. Genetic and phylogenetic analysis of the non-structural proteins NS1, NS2 and NS3 of epizootic haemorrhagic disease virus (EHDV). Virus Research 2009 Nov;145(2):211-9. Epub 2009 Aug 7.
  • Maan, S; Maan, N; Ross-Smith, N; Batten, CA; Shaw, AE; Anthony, SJ; Samuel, AR; Darpel, KE; Veronesi, E; Oura, C; Singh, KP; Nomikou, K; Potgieter, C; Attoui, H; van Rooij, E; van Rijn, P; De Clercq, K; Vandenbussche, F; Zientara, S; Breard, E; Sailleau, C; Beer, M; Hoffman, B; Mellor, PS; Mertens, PPC  (2008) Sequence analysis of bluetongue virus serotype 8 from the Netherlands 2006 and comparison to other European strains.  Journal of General Virology  377: 308-18.
  • Yadin, H; Brenner, J; Gelman, B; Bumbrov, V; Oved, Z; Stram, Y; Galon, N; Klement, E; Perl, S; Anthony, SJ; Maan, S; Batten, C; Mertens, PPC (2008)  Epizootic Haemorrhagic Disease Virus Type 7 infection in cattle in Israel, August-October 2006. Veterinary Record: 162: 53-56.
  • Anthony, SJ; Jones, H; Darpel, KE; Elliot, H; Maan, S; Samuel, AR; Mellor, PS; and Mertens, PPC (2007). A duplex RT-PCR assay for the detection of genome segment 7 (VP7 gene) from 24 serotypes.  Journal of Virological Methods 141, 188-197.
  • Darpel, KE; Batten, CA; Veronesi, E; Shaw, A; Anthony, SJ; Bachanek-Bankowska, K; Kgosana, L; bin-Tarif, A; Muller-Doblies, UU; Takamatsu, HH; Mellor, PS; Mertens, PPC; and Oura, C (2007). A study of British sheep and cattle infected with bluetongue virus serotype 8 from the 2006 outbreak in northern Europe. Veterinary Record 161: 253-261.
  • Maan, S; Rao, S; Maan, N; Anthony, S; Attoui, H; Samuel, A. R; and Mertens, PPC (2007). Rapid cDNA synthesis and sequencing techniques for the genetic study of bluetongue and other dsRNA viruses. Journal of Virological Methods143: 132-139.
  • Mertens, PPC; Maan, N; Prasad, G; Samuel, AR; Shaw, A; Potgieter, AC; Anthony, SJ; and Maan, S. (2007). The design of primers and use of RT-PCR assays for typing European BTV isolates: Differentiation of field and vaccine strains.Journal of General Virology 88: 2811-2823.
  • Shaw, A; Monaghan, P; Alpar, HO; Anthony, S; Darpel, KE; Batten, CA; Carpenter, S; Jones, H; Oura, C; King, DP; Elliot, H; and Mertens, PPC. (2007). Development and validation of a real-time RT-PCR assay to detect genome bluetongue virus segment 1. Journal of Virological Methods 145: 115-126.
Book Chapters
  • Attoui, H; Maan, S; Anthony, SJ; Mertens, PPC. (2009) Bluetongue virus, other orbiviruses and other reoviruses:Their relationships and taxonomy. In Bluetongue: (eds Mellor,PS; Baylis, M; Mertens, P.P.C). Academic Press, London. Pg: 23-52.
  • Maan, S; Maan, NS; Nomikou, K; Anthony, SJ;, Ross-Smith, N; Singh, KP; Samuel, AR; Shaw, AE; Mertens, PPC (2009) Molecular epidemiology studies of bluetongue virus. In Bluetongue: (eds Mellor,PS; Baylis, M; Mertens, PPC). Academic Press, London. Pg:135-166.
  • Darpel, KE; Monaghan, P; Anthony, SJ; Takamatsu, HH; and Mertens, PPC. (2009) Bluetongue virus in the mammalian host and the induced immune response. In Bluetonugue: (eds Mellor,PS; Baylis, M; Mertens, PPC). Academic Press, London. Pg:265-284.
  • Mertens, PPC; Maan, S; Batten, C; Darpel, KE; Shaw, AE; Maan, NS; Nomikou, K; Anthony, SJ; Veronesi, E; Oura, C; Carpenter, S; Mellor, PS. (2009) Bluetongue virus diagnosis. In Bluetonugue: (eds Mellor,PS; Baylis, M; Mertens, PPC). Academic Press, London. Pg: 365-428.