P. LAN QUAN, PH.D.

Associate Research Scientist 

Phone: 212-342-9031
Email: pq2106@columbia.edu

 
EDUCATION & TRAINING
  • University Paris X1, Paris, France, BS, 1998
  • University Paris VII, Paris, France, MS, 1999
  • University Paris VII, Paris, France, Ph.D., Virology, 2003

 

BIO

P. Lan Quan, Ph.D. is an Associate Research Scientist at the Center for Infection and Immunity. Dr. Quan completed her training in Virology at the University of Paris VII in 2003. Early research for Dr. Quan's doctoral work focused on the functional duality of the Spi-1/PU.1 oncogene involved in the erythroleukaemia of Friend virus, a strain of murine leukemia virus that is a well-established model for studying genetic resistance to infection by an immunosuppressive retrovirus. Dr. Quan's dissertation was on evidence of an apoptotic role of the HIV-1 gp41 transmembrane glycoprotein and consequences of antiviral strategies. Her postdoctoral training began at the Host-Pathogen Interaction Laboratory at the Cochin Institute in Paris, and was completed at the Center for Infection and Immunity until she accepted her current post.

SCIENTIFIC INTERESTS

Currently at CII, Dr. Quan's research focuses on emerging zoonoses and pathogen surveillance and discovery. Researching emerging infectious diseases is a dynamic field that encompasses the development of powerful assays to aid in pathogen discovery and characterization as well as enable effective surveillance. Quan helped to develop and validate the comprehensive viral oligonucleotide probe design pioneered by CII scientists. Quan's work has thus far included investigating the cause of disease outbreaks in bats and honeybees, transplant patients, pediatric severe respiratory tract infection, and more.

PUBLICATIONS

  • Diana L. Cox-Foster, Sean Conlan, Edward C. Holmes, Gustavo Palacios, Jay D. Evans, Nancy A. Moran, Phenix-Lan Quan, Thomas Briese, Mady Hornig, David M. Geiser, Vince Martinson, Dennis vanEngelsdorp, Abby L. Kalkstein, Andrew Drysdale, Jeffrey Hui, Junhui Zhai, Liwang Cui, Stephen K. Hutchison, Jan Fredrik Simons, Michael Egholm, Jeffery S. Pettis, W. Ian Lipkin. A metagenomic survey of microbes in honey bee colony collapse disorder. Science 2007 Oct12;318(5848) :283-7
  • Phenix-Lan Quan, Gustavo Palacios, Omar J. Jabado, Sean Conlan, David L. Hirschberg, Francisco Pozo, Philippa J.M. Jack, Daniel Cisterna, Neil Renwick, Jeffrey Hui, Andrew Drysdale, Rachel Amos-Ritchie, Elsa Baumeister, Vilma Savy, Kelly M. Lager, Jurgen A. Richt, David B. Boyle, Adolfo Garcia-Sastre, Inmaculada Casas, Pilar Perez-Breña, Thomas Briese, W. Ian Lipkin. Detection of respiratory viruses and subtype identification of influenza A viruses by GreeneChipResp oligonucleotide microarray. JClin Microbiol. 2007.
  • Palacios G, Quan P-L, Jabado OJ, Conlan S, Hirschberg DL, Liu Y, Renwick N, Hui J, Hegyi H, Grolla A, Strong JE, Towner JE, Geisbert TW, Jahrling P, Buchen-Osmond C, Ellerbrok H, Sanchez-Seco MP, Lussier Y, Formenty P, Nichol ST, Feldmann H, Briese T, Lipkin WI. Panmicrobial oligonucleotide array for diagnosis of infectious diseases. Emerg Infect Dis. 2007 Jan. Available from http://www.cdc.gov/ncidod/EID/13/1/73.htm
  • Delphine Delcroix-Genete, Phenix-Lan Quan, Marie-Gaelle Roger, Uriel Hazan, Sebastien Nisole, Cecile Rousseau. Retrovirology 2006. Antiviral properties of two soluble trimeric recombinant gp41 proteins (first two authors contributed equally).
  • Xavier Carnec, Lan Quan, William C. Olson, Uriel Hazan, Tatjana Dragic. Monoclonal antibodies that inhibit entry of human immunodefiency virus type-1 X4 strains interact exclusively with the second extracellular loop of CXCR4. J Virol. 2005.
  • Click here to see more publications.